Why are diseases that are found to be curable/reversible in mice?

not in humans?





Serious answers only please.





Asking b/c Rett Syndrome ( a devastating neurological disorder) was completely reversed in mice like 3 years ao %26amp; I don't understand why the same basic concepts that made that possible can't be used in living humans suffering from this horrible disease








OCTOBER IS RETT SYNDROME AWARENESS MONTH


Care Today-Cure tommorow !Why are diseases that are found to be curable/reversible in mice?
Great question and thanks for posting about Rett Syndrome and helping raise awareness!





In the experiments on mice (1 1/2 yr ago) they silenced the MECP2 in the mice (with insertion of a ';stop cassette';), and then un-silenced it to see if the effects would be permanent like they believed they would be. So the mice didn't actually have Rett Syndrome and in RS there is no ';stop cassette'; built into it to turn on again. So the real outcome of this study showed that once a cure/treatment is found, these girls could possibly be normal again and not neurologically damaged permanently...this is amazing in itself but doesn't mean we are any closer to a cure.